Sinapsos Podcast | Oncology

E51   |  9 min   |   Latest   |  Publication Link

• Podcast based on: Tepebasili, M.A.; Nazari, A.S.; Duzkalir, A.H.; Yildirim, D.C.; Askeroglu, M.O.; Veznikli, M.; Peker, S. Single-Session Versus Hypofractionated Gamma Knife Radiosurgery for Large Parasagittal Meningiomas: A Retrospective Comparative Study. Cancers 2026, 18, 3188. https://doi.org/10.3390/cancers18193188
  Type: Article  |  Publication date: 02 October 2026
  
  
• Summary: Parasagittal meningiomas (PSMs) are difficult to resect completely because they often involve the superior sagittal sinus, one of the brain’s major veins. As a result, Gamma Knife radiosurgery is commonly used as an alternative or complementary treatment. For larger tumors, single-session treatment may be limited by the risk of radiation-related edema. Dividing the treatment into several sessions may reduce this risk, but there is limited evidence for this approach in parasagittal meningiomas. We reviewed 87 patients with 87 large PSMs (≥8 cm3) treated at a single institution and compared outcomes between single-session and multi-session Gamma Knife radiosurgery. Freedom from local progression did not differ significantly between the groups (p = 0.137), nor did post-treatment radiological edema (p = 0.235) or new clinical symptoms (p = 0.744). These findings offer practical guidance for treating large parasagittal meningiomas and highlight the need for prospective studies to determine which patients benefit most from fractionated treatment.
  
  
• Keywords: parasagittal meningioma; Gamma Knife radiosurgery; hypofractionated radiosurgery; stereotactic radiosurgery; local control; peritumoral edema; superior sagittal sinus; large meningioma

License and disclaimer:
Original article © 2026 by the authors. Licensed under the Creative Commons Attribution 4.0 (CC BY 4.0) license (https://creativecommons.org/licenses/by/4.0/). This episode is an AI-generated audio adaptation of the article: the script and the voices are synthetic, changes were made, and the adaptation is not endorsed by the authors, the journal, or the publisher. It may contain errors or omissions, so consult the original publication before relying on any detail. It is for educational purposes only and is not medical advice. The creators accept no liability for any use of this content.