Sinapsos Podcast | Oncology

E46   |  11 min   |   Latest   |  Publication Link

• Podcast based on: Haimi, I.; Rajaram, R. Nodal Staging in Patients with Locally Advanced Non-Small Cell Lung Cancer: Indications, Approaches, and Impact on Downstream Treatment Selection. Cancers 2026, 18, 2561. https://doi.org/10.3390/cancers18162561
  Type: Review  |  Publication date: 10 August 2026
  
  
• Summary: Precise mediastinal lymph node staging is fundamental to the management of locally advanced non-small cell lung cancer (NSCLC). Nodal disease status is the primary determinant of prognosis in this population and directly governs eligibility for surgery, multimodality therapy, immunotherapy, and molecularly targeted treatments. As systemic options expand and therapeutic sequencing becomes increasingly complex, accurate nodal assessment is more critical than ever. This review examines contemporary mediastinal staging approaches and illustrates how nodal evaluation drives modern treatment selection in stage II-III NSCLC.
  
  
• Keywords: non-small cell lung cancer; mediastinal lymph node staging; endobronchial ultrasound-guided transbronchial needle aspiration; FDG-PET/CT; neoadjuvant chemoimmunotherapy; N2 disease classification; TNM ninth edition; perioperative immunotherapy; surgical resection; multidisciplinary treatment planning

License and disclaimer:
Original article © 2026 by the authors. Licensed under the Creative Commons Attribution 4.0 (CC BY 4.0) license (https://creativecommons.org/licenses/by/4.0/). This episode is an AI-generated audio adaptation of the article: the script and the voices are synthetic, changes were made, and the adaptation is not endorsed by the authors, the journal, or the publisher. It may contain errors or omissions, so consult the original publication before relying on any detail. It is for educational purposes only and is not medical advice. The creators accept no liability for any use of this content.